Developing next
generation DDR
targeting therapies

Inducing tumour cell death by
exploiting genomic instability
and replication stress

Our Mission

Nodus Oncology is developing first and best-in-class molecules inhibiting novel targets within the DNA damage response and replication stress response.

Supported by most recent scientific advances, we are developing the next wave of cancer therapeutics in the DNA damage response (DDR) area.

Founded by Cumulus Oncology and in partnership with the Lead Discovery Centre, Nodus Oncology is developing an innovative portfolio focused on synthetic lethality and collateral vulnerabilities in molecularly defined cancer patient populations.

Our Team

A mix of extensive scientific expertise and experienced commercial strategy to develop an ambitious start up with several development programmes to bring innovative drugs to patients.

Ian Waddell PhD

Chief Executive Officer

Research scientist with over 30 years experience in successful R&D programmes with extensive and in-depth oncology expertise of the DDR field.

Luis Toledo PhD

Scientific Founder & Advisor

Associate professor at the University of Copenhagen, with extensive in-depth expertise of the DDR field.

Nicola Broughton PhD, MBA

Chief Business Officer

A highly accomplished entrepreneur and investor in the life sciences sector with a deep expertise in due diligence, intellectual property (IP) matters, licensing activities, fund raising and deal negotiation.

Manuelle Debunne PhD

Chief Operating Officer

Entrepreneurial scientist with proven ability to manage academic and industry programmes to translate oncology assets towards clinical development.

Scott Doak

Chief Financial Officer

Entrepreneurial financial strategist with extensive experience of financial modelling and business management, deal negotiation and investor relations.

Scientific Advisory Board

Marcel van Vugt PhD

Professor of Molecular Oncology at the Department of Medical Oncology at the University of Groningen, The Netherlands

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Marcel van Vugt, PhD

Professor of Molecular Oncology at the Department of Medical Oncology at the University of Groningen, The Netherlands.

Marcel’s interest in the DDR started during his PhD at the Netherlands Cancer Institute in Amsterdam, under supervision of Prof. Rene Medema, where he studied Cell Cycle regulation by Polo-like kinase-1. This interest continued during his postdoctoral fellowship, where Marcel studied the regulation of the DNA damage checkpoint by cell cycle kinases in the laboratory of Michael B. Yaffe at the David H. Koch, at the institute for Integrative Cancer Research at the Massachusetts Institute of Technology (MIT, Cambridge USA). In 2009, Marcel started an independent research group at the University of Groningen where his research focuses on how normal cells and cancer cells deal with DNA damage, and how this knowledge can be used to improve cancer therapy. Since April 2018, Marcel is appointed Full Professor of Molecular Oncology, and since November 2018 he is director of the Cancer Research Center Groningen.

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Dominic James PhD, FRSB

VP of Translational Sciences at Imagen Therapeutics

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Dominic James, PhD., FRSB

VP of Translational Sciences at Imagen Therapeutics

Dominic has over 30 years’ experience in molecular and cellular biology with roles at the European Molecular Biology Laboratory, University of Geneva, AstraZeneca and the Cancer Research UK Manchester Institute (CRUK MI). He has successfully led drug discovery projects for CRUK MI from target identification through to licencing. Dominic is an enthusiastic and highly skilled scientist who was recently elected as a Fellow to the Royal Society of Biology.

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Jan Eickhoff PhD

Head of Screening and Assay Development at Lead Discovery Center in Dortmund, Germany

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Jan Eickhoff, PhD

Head of Screening and Assay Development at Lead Discovery Center in Dortmund, Germany

Jan has over 20 years of experience in oncology and drug discovery, holding positions at the Max-Planck Institute of Biochemistry, Axxima Pharmaceuticals and GPC Biotech. In addition, Jan was managing director of the HDC GmbH in Constance, Germany, and involved in planning and set up of the centralized compound management and screening unit of the Max Planck Society. He has a track record of successfully leading small molecule drug discovery projects, with several first-in class oncology projects currently being tested in clinical trials.    

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Luis Toledo PhD

Scientific Founder & SAB Chair

Associate professor at the University of Copenhagen, with extensive in-depth expertise of the DDR field.

Board of Directors

Ian Waddell PhD

Chief Executive Officer

DDR Experience: - PARPi, PARGi, ATR, DNA-PK and WRN

Scott Doak

Finance Director, Director

Group Finance Director at Cumulus Oncology

Julia Brown

Chairwoman

VP of Translational Sciences at Imagen Therapeutics

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Julia Brown, Chairwoman

Julia Brown

Chairwoman

Julia is an experienced Non-Exec Director and Chairperson with a broad scientific background and wealth of experience in both industry and the public sector. She led the transition of a novel biotech from bench to late-stage clinical testing and out-licensing. She co-founded a clinical CRO which successfully expanded its operations into the USA. Julia has worked closely with companies, government, and the higher education sector to support Scotland’s economic development. This included diligence on investment opportunities for Scottish Enterprise and the Scottish Investment Bank. Most recently, Julia was Chair of the UK Knowledge Transfer Network, KTN Ltd and former Non Exec Director of Cumulus Oncology.

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Keith Blundy

Non-Executive Director

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Keith Blundy, Non-Executive Director

Keith Blundy

NED

Former Chief Executive with experience in molecular biology R&D, drug discovery, strategy & licensing as well as extensive venture capital fund raising experience with a world leading cancer technology commercialisation company (Cancer Research Technology) and a pioneering biotech startup (Storm Therapeutics). He was formerly a director of KuDOS Pharmaceuticals Ltd, Mission Therapeutics, Cancer Therapeutics Pty and Inivata Ltd.

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Clare Wareing

Non-Executive Director

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Clare Wareing, Non-Executive Director

Clare Wareing

NED

Clare is the CEO of Cumulus Oncology, which founded Nodus Oncology. With a PhD in cancer cell biology from the University of Edinburgh and a 30-year career in clinical development in the oncology biopharmaceutical sector, Clare’s in-depth experience in the contract research organisation (CRO) sector has given her a wide exposure to different oncology asset classes and a highly valuable perspective on the key attributes for successful oncology drug development. Clare founded the niche CRO, Nexus Oncology, which became the partner company of choice for a number of biotechs developing new cancer therapies. Clare sold Nexus Oncology to Ockham Development in 2012 in a cash and share transaction, with a second successful exit two years later when Ockham was acquired by Chiltern Development.

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Do you have specific DDR expertise we need to know about?

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Partnerships

The Lead Discovery Center acts as the drug discovery partner for Nodus Oncology and participates in the development of all assets in the pipeline. This close collaboration enables rapid and efficient delivery of successful programmes.

Our drug discovery partner is Lead Discovery Center in Dortmund

https://www.lead-discovery.de/en/

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